DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - 4-methylbenzolsulfons

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Collection	D4 : Boss
Chemical Name	4-methylbenzolsulfons ( From PubChem : SORAFENIB TOSYLATE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 637.027 g/mol 4 10 8.4091 False(2/4)
Structure
InChI	InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
InChIKey	IVDHYUQIDRJSTI-UHFFFAOYSA-N
Links
Gene (160 / 187) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining ABCG2 BOSS Text Mining ADAM17 BOSS Text Mining ADAMTS13 BOSS Text Mining AFP BOSS Text Mining AK5 BOSS Text Mining AKR1B1 BOSS Text Mining ALB BOSS Text Mining ALK BOSS Text Mining ATP8A2 BOSS Text Mining AURKB BOSS Text Mining BBS9 BOSS Text Mining BCL2 BOSS Text Mining BCL2L1 BOSS Text Mining BECN1 BOSS Text Mining BID BOSS Text Mining C7orf49 BOSS Text Mining CASP3 BOSS Text Mining CASP8 BOSS Text Mining CASP9 BOSS Text Mining CCNB1 BOSS Text Mining CD34 BOSS Text Mining CD4 BOSS Text Mining CDH2 BOSS Text Mining CDKN2A BOSS Text Mining CDT1 BOSS Text Mining COG3 BOSS Text Mining COX8C BOSS Text Mining CSF2 BOSS Text Mining CSF3 BOSS Text Mining CXCL12 BOSS Text Mining CYCS BOSS Text Mining CYGB BOSS Text Mining CYP2C8 BOSS Text Mining DCR BOSS Text Mining DDR2 BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining EIF4EBP1 BOSS Text Mining ELF3 BOSS Text Mining EPHB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB2 BOSS Text Mining F9 BOSS Text Mining FAM109A BOSS Text Mining FAM126A BOSS Text Mining FGF13 BOSS Text Mining FLT1 BOSS Text Mining FLT4 BOSS Text Mining GCK BOSS Text Mining GINS1 BOSS Text Mining GYPE BOSS Text Mining HBA1 BOSS Text Mining HBB BOSS Text Mining HLP BOSS Text Mining HPD BOSS Text Mining HRAS BOSS Text Mining HSD17B1 BOSS Text Mining IDE BOSS Text Mining IFNA1 BOSS Text Mining IFNA17 BOSS Text Mining IFT46 BOSS Text Mining IGFBP1 BOSS Text Mining IL10 BOSS Text Mining IL2 BOSS Text Mining IL3 BOSS Text Mining IL6 BOSS Text Mining INS BOSS Text Mining JAK2 BOSS Text Mining KDR BOSS Text Mining KIT BOSS Text Mining KRT19 BOSS Text Mining LARP6 BOSS Text Mining LDHA BOSS Text Mining MAP3K1 BOSS Text Mining MAPK14 BOSS Text Mining MAPK3 BOSS Text Mining MCL1 BOSS Text Mining MET BOSS Text Mining MMP9 BOSS Text Mining MTOR BOSS Text Mining MYC BOSS Text Mining NFKB2 BOSS Text Mining NSG1 BOSS Text Mining OPTN BOSS Text Mining OXSM BOSS Text Mining PARP2 BOSS Text Mining PAX3 BOSS Text Mining PCNA BOSS Text Mining PDGFRA BOSS Text Mining PDGFRB BOSS Text Mining PGF BOSS Text Mining PGP BOSS Text Mining PLXNA3 BOSS Text Mining POLD4 BOSS Text Mining PPARG BOSS Text Mining PR@ BOSS Text Mining PRDX2 BOSS Text Mining PTEN BOSS Text Mining PTK2B BOSS Text Mining RAF1 BOSS Text Mining RASGRF1 BOSS Text Mining RBM15 BOSS Text Mining RBP3 BOSS Text Mining RHO BOSS Text Mining RNASEH2A BOSS Text Mining RPN2 BOSS Text Mining RPS6KB1 BOSS Text Mining SETD2 BOSS Text Mining SGSM3 BOSS Text Mining SLC17A5 BOSS Text Mining SLC22A1 BOSS Text Mining SMUG1 BOSS Text Mining SNRPN BOSS Text Mining STAT3 BOSS Text Mining TACR2 BOSS Text Mining TEK BOSS Text Mining TFE3 BOSS Text Mining TG BOSS Text Mining THM BOSS Text Mining TIMM8A BOSS Text Mining TLK2 BOSS Text Mining TM7SF2 BOSS Text Mining TNF BOSS Text Mining TNFRSF10B BOSS Text Mining TNFSF10 BOSS Text Mining TP53 BOSS Text Mining TPM3 BOSS Text Mining TRAPPC9 BOSS Text Mining TSC1 BOSS Text Mining VEGFA BOSS Text Mining VHL BOSS Text Mining XRCC1 BOSS Text Mining ZHX2 PubChem None uM ADAM10 - GI(Protien) : PubChem None uM ADAM10 - GI(Protien) : PubChem None uM ADAM17 - GI(Protien) : PubChem None uM ADAM17 - GI(Protien) : PubChem Potency-Replicate_1 uM 8.485 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 9.439 AR - GI(Protien) : PubChem Potency uM 15.849 ATXN2 - GI(Protien) : PubChem None uM CFTR - GI(Protien) : PubChem None uM CHRM4 - GI(Protien) : PubChem None uM CHRM5 - GI(Protien) : PubChem Potency-Replicate_1 uM 11.883 CYP19A1 - GI(Protien) : PubChem None uM DRD3 - GI(Protien) : PubChem Potency-Replicate_1 uM 6.007 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 6.242 ESR1 - GI(Protien) : PubChem Potency uM 16.360 GMNN - GI(Protien) : PubChem None uM HCRTR1 - GI(Protien) : PubChem None uM IL1B - GI(Protien) : PubChem IC50 uM 4.480 MC4R - GI(Protien) : PubChem None uM MC4R - GI(Protien) : PubChem None uM MC4R - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem None uM NCOA2 - GI(Protien) : PubChem None uM NCOA2 - GI(Protien) : PubChem Potency uM 25.929 NFE2L2 - GI(Protien) : PubChem None uM NR2E3 - GI(Protien) : PubChem None uM NR2E3 - GI(Protien) : PubChem None uM NR2F2 - GI(Protien) : PubChem None uM NR2F2 - GI(Protien) : PubChem None uM NR5A1 - GI(Protien) : PubChem None uM NR5A2 - GI(Protien) : PubChem EC50_Mean uM 14.600 NTSR1 - GI(Protien) : PubChem None uM NTSR1 - GI(Protien) : PubChem None uM NTSR1 - GI(Protien) : PubChem AC50_uM uM 5.300 PAX8 - GI(Protien) : PubChem None uM PAX8 - GI(Protien) : PubChem Potency-Replicate_1 uM 10.590 PPARG - GI(Protien) : PubChem None uM PRNP - GI(Protien) : PubChem None uM TAAR1 - GI(Protien) : PubChem Potency uM 11.886 TDP1 - GI(Protien) : PubChem Potency uM 14.963 TDP1 - GI(Protien) : PubChem Potency uM 20.596 TDP1 - GI(Protien) : PubChem Potency uM 23.109 TDP1 - GI(Protien) : PubChem None uM TNFRSF10B - GI(Protien) : PubChem None uM TNFRSF10B - GI(Protien) : PubChem None uM TNFRSF10B - GI(Protien) : PubChem None uM UCHL5 - GI(Protien) : ChEMBL Potency nM 25929.000 NFE2L2 - Target : CHEMBL1075094 ChEMBL EC50 nM 14600.000 NTSR1 - Target : CHEMBL4123
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