Tan Lab | DSigDB

Gene Set: D4 : Boss - inlyta

Collection

D4 : Boss

Chemical Name

inlyta ( From PubChem : AXITINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
386.47 g/mol	2	5	5.03	False(3/4)

Structure

InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

InChIKey

Links

Gene (21 / 25)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
BOSS	Text Mining			ABCG2
BOSS	Text Mining			AURKB
BOSS	Text Mining			CDT1
BOSS	Text Mining			CYGB
BOSS	Text Mining			CYP2C8
BOSS	Text Mining			DDR2
BOSS	Text Mining			FLT1
BOSS	Text Mining			HLP
BOSS	Text Mining			IL2
BOSS	Text Mining			KDR
BOSS	Text Mining			KIT
BOSS	Text Mining			MTOR
BOSS	Text Mining			PDGFRB
BOSS	Text Mining			PPARG
BOSS	Text Mining			VEGFA
BOSS	Text Mining			XRCC1
PubChem	AhR Potency (uM)	uM	2.282	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.758	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.084	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.740	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.893	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.057	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	2.661	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.217	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.688	YES1		GI(Protien) :

Download gene sets