Tan Lab | DSigDB

Gene Set: D4 : Boss - glaxosmithkline brand of lamotrigine

Collection

D4 : Boss

Chemical Name

glaxosmithkline brand of lamotrigine ( From PubChem : LAMOTRIGINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
256.091 g/mol	2	5	3.1722	True

Structure

InChI

InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey

Links

Gene (22 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
BOSS	Text Mining			BBS9
BOSS	Text Mining			BDNF-AS
BOSS	Text Mining			C7orf49
BOSS	Text Mining			CDT1
BOSS	Text Mining			CYGB
BOSS	Text Mining			CYP2C8
BOSS	Text Mining			DDR2
BOSS	Text Mining			GYPE
BOSS	Text Mining			INS
BOSS	Text Mining			MTR
BOSS	Text Mining			NACC1
BOSS	Text Mining			POMC
BOSS	Text Mining			SLC25A20
BOSS	Text Mining			SLC6A3
BOSS	Text Mining			TNFRSF14
BOSS	Text Mining			UGT2B7
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
ChEMBL	Activity	-		AQP4	-	Target : CHEMBL5964
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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