Tan Lab | DSigDB

Gene Set: D1 - Approved - CLOFARABINE

Collection

D1 : Approved

Chemical Name

CLOFARABINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
303.677 g/mol	3	8	0.2318	True

Structure

InChI

InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChIKey

Links

Gene (12 / 19)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Ratio Potency (uM)	uM	10.682	AR	-	GI(Protien) :
PubChem	Potency	uM	13.448	AR	-	GI(Protien) :
PubChem		uM		CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	3.758	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	6.431	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	2.196	NFE2L2	-	GI(Protien) :
PubChem		uM		POLA1	-	GI(Protien) :
PubChem		uM		POLD1	-	GI(Protien) :
PubChem		uM		POLE	-	GI(Protien) :
PubChem		uM		RRM1		GI(Protien) :
PubChem		uM		RRM1		GI(Protien) :
PubChem		uM		RRM2		GI(Protien) :
PubChem		uM		RRM2		GI(Protien) :
PubChem		uM		RRM2B		GI(Protien) :
PubChem		uM		RRM2B		GI(Protien) :
PubChem	Potency	uM	0.002	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.002	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.084	TP53	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.097	TP53	-	GI(Protien) :

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