Tan Lab | DSigDB

Gene Set: D1 - Approved - CILOSTAZOL

Collection

D1 : Approved

Chemical Name

CILOSTAZOL

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
369.461 g/mol	1	7	3.6027	True

Structure

InChI

InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

InChIKey

Links

Gene (15 / 26)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Potency	uM	25.119	ALDH1A1	-	GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem	IC50	uM	10.000	CYP2C9	-	GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem	Potency	uM	12.589	CYP3A4	-	GI(Protien) :
PubChem		uM		CYP3A4	-	GI(Protien) :
PubChem		uM		DRD1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.832	NFE2L2	-	GI(Protien) :
PubChem		uM		NPY1R	-	GI(Protien) :
PubChem		uM		NPY1R	-	GI(Protien) :
PubChem		uM		NPY2R	-	GI(Protien) :
PubChem		uM		NR5A1	-	GI(Protien) :
PubChem		uM		NR5A2	-	GI(Protien) :
PubChem		uM		PDE3A	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.119	TSHR	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	12589.200	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	25118.900	TSHR	-	Target : CHEMBL1963

Download gene sets