Tan Lab | DSigDB

Gene Set: D1 - Approved - TOPOTECAN

Collection

D1 : Approved

Chemical Name

TOPOTECAN

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
421.446 g/mol	2	8	1.8468	True

Structure

InChI

InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChIKey

UCFGDBYHRUNTLO-QHCPKHFHSA-N

Links

Gene (6 / 20)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
PubChem		uM		AKT1		GI(Protien) :
PubChem	IC50	uM	1.521	CYP3A4	-	GI(Protien) :
PubChem	IC50	uM	0.060	HIF1A		GI(Protien) :
PubChem	IC50	uM	1.300	SLC47A1		GI(Protien) :
PubChem	IC50	uM	8.600	SLC47A2		GI(Protien) :
PubChem	IC50	uM	0.050	TOP1		GI(Protien) :
PubChem	EC50	uM	0.054	TOP1		GI(Protien) :
PubChem	EC50	uM	0.071	TOP1		GI(Protien) :
PubChem	IC50	uM	5.250	TOP1	-	GI(Protien) :
PubChem	IC50	uM	5.550	TOP1	-	GI(Protien) :
PubChem	IC50	uM	9.650	TOP1	-	GI(Protien) :
PubChem		uM		TOP1		GI(Protien) :
PubChem		uM		TOP1		GI(Protien) :
PubChem		uM		TOP1		GI(Protien) :
PubChem		uM		TOP1		GI(Protien) :
ChEMBL	Inhibition	-		AKT1	-	Target : CHEMBL4282
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781

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