Tan Lab | DSigDB

Gene Set: D1 - Approved - TRIAMCINOLONE

Collection

D1 : Approved

Chemical Name

TRIAMCINOLONE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
394.434 g/mol	4	6	0.6205	True

Structure

InChI

InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChIKey

GFNANZIMVAIWHM-OBYCQNJPSA-N

Links

Gene (15 / 42)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem		uM		ABCC1	-	GI(Protien) :
PubChem	Potency	uM	0.027	AR	-	GI(Protien) :
PubChem	Potency	uM	0.067	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.962	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	12.454	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	24.541	AR	-	GI(Protien) :
PubChem		uM		CFTR	-	GI(Protien) :
PubChem		uM		CHRM1	-	GI(Protien) :
PubChem		uM		CHRM5	-	GI(Protien) :
PubChem		uM		CTSL	-	GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem	Potency	uM	4.731	ESR1	-	GI(Protien) :
PubChem	Potency	uM	48.558	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.082	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.092	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.411	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.028	NFKB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.032	NR3C1	-	GI(Protien) :
PubChem	IC50	uM	0.058	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.062	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.112	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.301	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.338	NR3C1	-	GI(Protien) :
PubChem		uM		NR3C1		GI(Protien) :
PubChem		uM		NR3C1		GI(Protien) :
PubChem		uM		NR3C1		GI(Protien) :
PubChem		uM		NR3C1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	82.000	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	410.900	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	28.200	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	112.200	NR3C1	-	Target : CHEMBL2034

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