Tan Lab | DSigDB

Gene Set: D1 - Approved - BRIMONIDINE

Collection

D1 : Approved

Chemical Name

BRIMONIDINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
292.135 g/mol	2	5	1.6008	True

Structure

InChI

InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChIKey

Links

Gene (15 / 29)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Ki	uM	1.800	ADRA1A		GI(Protien) :
PubChem	Ki	uM	1.900	ADRA1A	-	GI(Protien) :
PubChem	Ki	uM	1.800	ADRA1B		GI(Protien) :
PubChem	Ki	uM	1.900	ADRA1B	-	GI(Protien) :
PubChem	IC50	uM	1.720	ADRA1D	-	GI(Protien) :
PubChem	Ki	uM	1.800	ADRA1D		GI(Protien) :
PubChem	Ki	uM	1.900	ADRA1D	-	GI(Protien) :
PubChem	Ki	uM	0.003	ADRA2A		GI(Protien) :
PubChem	IC50	uM	0.298	ADRA2A	-	GI(Protien) :
PubChem	EC50	uM	11.400	ADRA2A		GI(Protien) :
PubChem	IC50	uM	1.047	ADRA2B	-	GI(Protien) :
PubChem	EC50	uM	11.400	ADRA2B		GI(Protien) :
PubChem	Ki	uM	0.044	ADRA2C		GI(Protien) :
PubChem	EC50	uM	11.400	ADRA2C		GI(Protien) :
PubChem	Potency	uM	15.849	ALDH1A1	-	GI(Protien) :
PubChem		uM		DLD	-	GI(Protien) :
PubChem	Potency	uM	22.387	HPGD	-	GI(Protien) :
PubChem		uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	Potency	uM	18.888	RGS4	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Potency	nM	15848.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	18887.600	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15848.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	22387.200	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	19952.600	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	18887.600	RGS4	-	Target : CHEMBL1795091
ChEMBL	Potency	nM	44668.400	VDR	-	Target : CHEMBL1977

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