Tan Lab | DSigDB

Gene Set: D1 - Approved - MEGESTROL ACETATE

Collection

D1 : Approved

Chemical Name

MEGESTROL ACETATE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
384.508 g/mol	0	4	4.5753	True

Structure

InChI

InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

InChIKey

RQZAXGRLVPAYTJ-GQFGMJRRSA-N

Links

Gene (7 / 22)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Potency	uM	0.043	AR	-	GI(Protien) :
PubChem	Potency	uM	0.090	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.347	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.422	AR	-	GI(Protien) :
PubChem	Potency	uM	0.574	AR	-	GI(Protien) :
PubChem	IC50	uM	10.000	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	0.731	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.871	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	11.882	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	19.331	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	3.981	NPSR1	-	GI(Protien) :
PubChem	IC50	uM	0.019	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.078	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.091	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		NR3C1	-	GI(Protien) :
PubChem		uM		NR3C1	-	GI(Protien) :
PubChem		uM		NR3C1	-	GI(Protien) :
PubChem		uM		PGR		GI(Protien) :
PubChem		uM		PGR		GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	730.800	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	3981.100	NPSR1	-	Target : CHEMBL5162

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