Tan Lab | DSigDB

Gene Set: D1 - Approved - MITOMYCIN C

Collection

D1 : Approved

Chemical Name

MITOMYCIN C

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
334.327 g/mol	3	9	0.0161	True

Structure

InChI

InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChIKey

NWIBSHFKIJFRCO-WUDYKRTCSA-N

Links

Gene (16 / 31)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Potency	uM	13.333	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	16.154	AR	-	GI(Protien) :
PubChem	Potency	uM	29.849	CYP19A1	-	GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem	Potency	uM	6.682	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	8.096	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	15.679	ESR1	-	GI(Protien) :
PubChem	Potency	uM	21.314	ESR1	-	GI(Protien) :
PubChem	Ki	uM	25.000	IDO1		GI(Protien) :
PubChem		uM		NR1H4	-	GI(Protien) :
PubChem	Potency	uM	21.314	NR3C1	-	GI(Protien) :
PubChem		uM		PPARD	-	GI(Protien) :
PubChem		uM		PPARG	-	GI(Protien) :
PubChem		uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.009	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.009	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.581	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.731	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.883	TP53	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	2.818	TP53	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

Download gene sets

gmt, text, Detailed text