Tan Lab | DSigDB

Gene Set: D1 - Approved - PROTRIPTYLINE

Collection

D1 : Approved

Chemical Name

PROTRIPTYLINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
263.377 g/mol	1	1	4.6928	True

Structure

InChI

InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

InChIKey

Links

Gene (8 / 24)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	0.001	ADORA3		GI(Protien) :
PubChem	Potency	uM	3.981	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem		uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	11.220	DRD1	-	GI(Protien) :
PubChem		uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	8.912	NFKB1	-	GI(Protien) :
PubChem	Kd	uM	0.001	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.002	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.002	SLC6A2		GI(Protien) :
PubChem	Ki	uM	0.002	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.003	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.007	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.009	SLC6A2		GI(Protien) :
PubChem	IC50	uM	0.017	SLC6A2		GI(Protien) :
PubChem	Potency	uM	10.000	THPO	-	GI(Protien) :
ChEMBL	AC50	nM	3981.070	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3981.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	11220.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	8912.500	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	10000.000	THPO	-	Target : CHEMBL1293256

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