Tan Lab | DSigDB

Gene Set: D1 - Approved - PROMETHAZINE

Collection

D1 : Approved

Chemical Name

PROMETHAZINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
284.419 g/mol	0	2	4.3044	True

Structure

InChI

InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3/t13-/m1/s1

InChIKey

Links

Gene (26 / 35)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	0.183	ADRA1D	-	GI(Protien) :
PubChem	IC50	uM	0.681	ADRA2A	-	GI(Protien) :
PubChem	IC50	uM	0.053	ADRA2B	-	GI(Protien) :
PubChem	IC50	uM	2.431	ADRA2C	-	GI(Protien) :
PubChem	Potency	uM	17.783	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	39.811	CBX1	-	GI(Protien) :
PubChem	IC50	uM	0.014	CHRM1	-	GI(Protien) :
PubChem	IC50	uM	0.035	CHRM2	-	GI(Protien) :
PubChem	IC50	uM	0.020	CHRM3	-	GI(Protien) :
PubChem	IC50	uM	0.008	CHRM4	-	GI(Protien) :
PubChem	IC50	uM	0.005	CHRM5	-	GI(Protien) :
PubChem	IC50	uM	2.744	DRD1	-	GI(Protien) :
PubChem	Potency	uM	10.000	DRD1	-	GI(Protien) :
PubChem	IC50	uM	0.100	DRD2		GI(Protien) :
PubChem	IC50	uM	0.779	DRD2	-	GI(Protien) :
PubChem	IC50	uM	0.559	DRD3	-	GI(Protien) :
PubChem	IC50	uM	0.003	HRH1	-	GI(Protien) :
PubChem	IC50	uM	0.005	HRH1		GI(Protien) :
PubChem	IC50	uM	1.165	HRH2	-	GI(Protien) :
PubChem	IC50	uM	0.023	HTR2A		GI(Protien) :
PubChem	IC50	uM	0.067	HTR2A	-	GI(Protien) :
PubChem	IC50	uM	0.068	HTR2B	-	GI(Protien) :
PubChem	IC50	uM	0.012	HTR2C	-	GI(Protien) :
PubChem	IC50	uM	2.429	HTR6	-	GI(Protien) :
PubChem	Potency	uM	28.184	HTT	-	GI(Protien) :
PubChem	IC50	uM	0.287	SIGMAR1	-	GI(Protien) :
PubChem	IC50	uM	35.100	SLC22A1		GI(Protien) :
PubChem	IC50	uM	4.238	SLC6A2	-	GI(Protien) :
PubChem	IC50	uM	4.010	SLC6A4	-	GI(Protien) :
PubChem	IC50	uM	7.590	SLC6A4		GI(Protien) :
ChEMBL	Potency	nM	17782.800	ATXN2	-	Target : CHEMBL1795085
ChEMBL	Potency	nM	39810.700	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	10000.000	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	15003.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	28183.800	HTT	-	Target : CHEMBL5514

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