Tan Lab | DSigDB

Gene Set: D1 - Approved - ORPHENADRINE

Collection

D1 : Approved

Chemical Name

ORPHENADRINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
269.381 g/mol	0	2	3.6626	True

Structure

InChI

InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3/t18-/m0/s1

InChIKey

Links

Gene (19 / 19)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	2.156	ADRA2A	-	GI(Protien) :
PubChem	IC50	uM	1.895	ADRA2B	-	GI(Protien) :
PubChem	IC50	uM	0.148	CHRM1	-	GI(Protien) :
PubChem	IC50	uM	0.376	CHRM2	-	GI(Protien) :
PubChem	IC50	uM	0.175	CHRM3	-	GI(Protien) :
PubChem	IC50	uM	0.125	CHRM4	-	GI(Protien) :
PubChem	IC50	uM	0.028	CHRM5	-	GI(Protien) :
PubChem	IC50	uM	0.400	CYP2D6	-	GI(Protien) :
PubChem	IC50	uM	1.241	HRH1	-	GI(Protien) :
PubChem	IC50	uM	6.961	HRH2	-	GI(Protien) :
PubChem	IC50	uM	0.436	HTR2A	-	GI(Protien) :
PubChem	IC50	uM	3.391	HTR2B	-	GI(Protien) :
PubChem	IC50	uM	0.534	HTR2C	-	GI(Protien) :
PubChem	IC50	uM	1.121	HTR6	-	GI(Protien) :
PubChem	IC50	uM	0.851	KCNH2		GI(Protien) :
PubChem	IC50	uM	12.600	SLC22A1		GI(Protien) :
PubChem	IC50	uM	2.500	SLC22A2		GI(Protien) :
PubChem	IC50	uM	2.666	SLC6A2	-	GI(Protien) :
PubChem	IC50	uM	0.458	SLC6A4	-	GI(Protien) :

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