Tan Lab | DSigDB

Gene Set: D1 - Approved - NORTRIPTYLINE

Collection

D1 : Approved

Chemical Name

NORTRIPTYLINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
263.377 g/mol	1	1	4.2173	True

Structure

InChI

InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3

InChIKey

PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Links

Gene (26 / 45)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	0.273	ADRA1D	-	GI(Protien) :
PubChem	IC50	uM	0.732	ADRA2A	-	GI(Protien) :
PubChem	IC50	uM	0.094	ADRA2B	-	GI(Protien) :
PubChem	IC50	uM	0.203	ADRA2C	-	GI(Protien) :
PubChem	Potency	uM	15.849	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	17.783	ATXN2	-	GI(Protien) :
PubChem	IC50	uM	0.082	CHRM1	-	GI(Protien) :
PubChem	IC50	uM	0.347	CHRM2	-	GI(Protien) :
PubChem	IC50	uM	0.171	CHRM3	-	GI(Protien) :
PubChem	IC50	uM	0.095	CHRM4	-	GI(Protien) :
PubChem	IC50	uM	0.027	CHRM5	-	GI(Protien) :
PubChem		uM		CYP1A2	-	GI(Protien) :
PubChem	IC50	uM	3.000	CYP2C19	-	GI(Protien) :
PubChem	IC50	uM	1.000	CYP2D6	-	GI(Protien) :
PubChem	IC50	uM	2.300	CYP2D6		GI(Protien) :
PubChem	Potency	uM	3.162	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem		uM		CYP2D6	-	GI(Protien) :
PubChem	IC50	uM	0.539	DRD1	-	GI(Protien) :
PubChem	Potency	uM	19.953	DRD1	-	GI(Protien) :
PubChem	IC50	uM	0.179	DRD3	-	GI(Protien) :
PubChem	IC50	uM	0.050	HRH1	-	GI(Protien) :
PubChem	IC50	uM	2.334	HRH2	-	GI(Protien) :
PubChem	IC50	uM	0.051	HTR2A	-	GI(Protien) :
PubChem	IC50	uM	0.136	HTR2B	-	GI(Protien) :
PubChem	IC50	uM	0.016	HTR2C	-	GI(Protien) :
PubChem	Ki	uM	0.214	HTR6		GI(Protien) :
PubChem	IC50	uM	0.554	HTR6	-	GI(Protien) :
PubChem	IC50	uM	0.003	SLC6A2	-	GI(Protien) :
PubChem	IC50	uM	1.678	SLC6A3	-	GI(Protien) :
PubChem	IC50	uM	0.013	SLC6A4	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	ATXN2	-	Target : CHEMBL1795085
ChEMBL	Potency	nM	17782.800	ATXN2	-	Target : CHEMBL1795085
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	19952.600	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096

Download gene sets

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