Tan Lab | DSigDB

Gene Set: D1 - Approved - MEFENAMIC ACID

Collection

D1 : Approved

Chemical Name

MEFENAMIC ACID

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
241.285 g/mol	2	2	3.8182	True

Structure

InChI

InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

InChIKey

HYYBABOKPJLUIN-UHFFFAOYSA-N

Links

Gene (14 / 40)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Ki	uM	0.810	AKR1C1		GI(Protien) :
PubChem	IC50	uM	3.910	AKR1C1		GI(Protien) :
PubChem	Ki	uM	0.220	AKR1C2		GI(Protien) :
PubChem	IC50	uM	6.970	AKR1C2		GI(Protien) :
PubChem	Ki	uM	0.300	AKR1C3		GI(Protien) :
PubChem	IC50	uM	0.560	AKR1C3		GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP1A2	-	GI(Protien) :
PubChem		uM		CYP1A2	-	GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C9	-	GI(Protien) :
PubChem		uM		CYP2C9	-	GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	61.131	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	43.641	PPARG	-	GI(Protien) :
PubChem		uM		PPARG	-	GI(Protien) :
PubChem	IC50	uM	0.116	PTGS1	-	GI(Protien) :
PubChem	IC50	uM	25.000	PTGS1		GI(Protien) :
PubChem		uM		PTGS1		GI(Protien) :
PubChem		uM		PTGS1		GI(Protien) :
PubChem	IC50	uM	0.602	PTGS2	-	GI(Protien) :
PubChem	IC50	uM	2.900	PTGS2		GI(Protien) :
PubChem		uM		PTGS2		GI(Protien) :
PubChem		uM		PTGS2		GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	7943.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	7943.280	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	61130.600	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	11.200	TDP1	-	Target : CHEMBL1075138

Download gene sets

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