Tan Lab | DSigDB

Gene Set: D1 - Approved - IMIPRAMINE

Collection

D1 : Approved

Chemical Name

IMIPRAMINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
280.407 g/mol	0	1	3.94	True

Structure

InChI

InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

InChIKey

BCGWQEUPMDMJNV-UHFFFAOYSA-N

Links

Gene (19 / 48)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	0.004	ADORA3		GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	25.119	CYP2D6	-	GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP2D6	-	GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem	Potency	uM	14.125	DRD1	-	GI(Protien) :
PubChem	IC50	uM	0.410	DRD2		GI(Protien) :
PubChem	IC50	uM	0.027	HRH1		GI(Protien) :
PubChem	IC50	uM	0.220	HTR2A		GI(Protien) :
PubChem	IC50	uM	3.388	KCNH2		GI(Protien) :
PubChem	IC50	uM	3.388	KCNH2		GI(Protien) :
PubChem	IC50	uM	3.388	KCNH2		GI(Protien) :
PubChem	IC50	uM	3.388	KCNH2		GI(Protien) :
PubChem	IC50	uM	3.388	KCNH2		GI(Protien) :
PubChem	IC50	uM	3.400	KCNH2		GI(Protien) :
PubChem	IC50	uM	17.100	SLC22A1		GI(Protien) :
PubChem	IC50	uM	37.000	SLC22A1		GI(Protien) :
PubChem	IC50	uM	0.600	SLC22A2		GI(Protien) :
PubChem	IC50	uM	10.000	SLC47A1		GI(Protien) :
PubChem	IC50	uM	0.074	SLC6A2		GI(Protien) :
PubChem	IC50	uM	25.600	SLC6A3		GI(Protien) :
PubChem	Ki	uM	0.001	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.001	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.002	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.004	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.007	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.007	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.007	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.008	SLC6A4		GI(Protien) :
PubChem	IC50	uM	0.029	SLC6A4		GI(Protien) :
PubChem	Potency	uM	29.855	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	14125.400	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	25118.900	EHMT2	-	Target : CHEMBL6032

Download gene sets

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