Tan Lab | DSigDB

Gene Set: D1 - Approved - HYDRALAZINE

Collection

D1 : Approved

Chemical Name

HYDRALAZINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
160.176 g/mol	2	4	1.6887	True

Structure

InChI

InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)

InChIKey

Links

Gene (12 / 28)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	Potency	uM	0.820	ATAD5	-	GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP1A2	-	GI(Protien) :
PubChem		uM		CYP1A2	-	GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem	Potency	uM	2.593	NPC1	-	GI(Protien) :
PubChem	Potency	uM	7.943	PKM	-	GI(Protien) :
PubChem	Potency	uM	2.311	RAB9A	-	GI(Protien) :
PubChem	Potency	uM	3.981	SMN2	-	GI(Protien) :
PubChem	Potency	uM	0.040	THPO	-	GI(Protien) :
ChEMBL	Potency	nM	819.600	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	2592.900	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	7943.300	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	2310.900	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	3981.100	SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	39.800	THPO	-	Target : CHEMBL1293256

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