Tan Lab | DSigDB

Gene Set: D1 - Approved - TETRACYCLINE

Collection

D1 : Approved

Chemical Name

TETRACYCLINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
444.435 g/mol	6	10	0.3293	False(3/4)

Structure

InChI

InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChIKey

NWXMGUDVXFXRIG-WESIUVDSSA-N

Links

Gene (19 / 38)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem		uM		ADRBK1	-	GI(Protien) :
PubChem		uM		BCL2L1	-	GI(Protien) :
PubChem		uM		CYP1A2		GI(Protien) :
PubChem		uM		CYP2C19		GI(Protien) :
PubChem		uM		CYP2C9		GI(Protien) :
PubChem		uM		CYP2D6		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		CYP3A4		GI(Protien) :
PubChem		uM		ESR1	-	GI(Protien) :
PubChem		uM		ESR2	-	GI(Protien) :
PubChem		uM		F2RL1		GI(Protien) :
PubChem		uM		F2RL1		GI(Protien) :
PubChem		uM		F2RL1		GI(Protien) :
PubChem		uM		GSTO1	-	GI(Protien) :
PubChem	IC50	uM	22.447	HSP90AA1	-	GI(Protien) :
PubChem		uM		HSP90AA1	-	GI(Protien) :
PubChem		uM		HTT	-	GI(Protien) :
PubChem		uM		HTT	-	GI(Protien) :
PubChem		uM		MCL1	-	GI(Protien) :
PubChem		uM		PLA2G7	-	GI(Protien) :
PubChem		uM		PPP1CA	-	GI(Protien) :
PubChem	IC50	uM	8.330	PTPN7	-	GI(Protien) :
PubChem		uM		SOD1	-	GI(Protien) :
PubChem		uM		SOD1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	IC50	nM	22447.400	HSP90AA1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	22447.400	HSP90AB1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	8330.000	PTPN7	-	Target : CHEMBL2219
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354

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