Tan Lab | DSigDB

Gene Set: D1 - Approved - PAZOPANIB HYDROCHLORIDE

Collection

D1 : Approved

Chemical Name

PAZOPANIB HYDROCHLORIDE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
473.979 g/mol	3	7	5.7951	False(3/4)

Structure

InChI

InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H

InChIKey

MQHIQUBXFFAOMK-UHFFFAOYSA-N

Links

Gene (28 / 37)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem		uM		CSF1R	-	GI(Protien) :
PubChem		uM		FGFR1	-	GI(Protien) :
PubChem		uM		FGFR3	-	GI(Protien) :
PubChem		uM		FLT1	-	GI(Protien) :
PubChem		uM		FLT4	-	GI(Protien) :
PubChem		uM		ITK	-	GI(Protien) :
PubChem		uM		KDR	-	GI(Protien) :
PubChem		uM		KIT	-	GI(Protien) :
PubChem		uM		LCK	-	GI(Protien) :
PubChem		uM		PDGFRA	-	GI(Protien) :
PubChem		uM		PDGFRB	-	GI(Protien) :
ChEMBL	Ki	nM	316.230	ABL1	-	Target : CHEMBL1862
ChEMBL	Ki	nM	1584.890	ALK	-	Target : CHEMBL4247
ChEMBL	Ki	nM	1258.930	AURKB	-	Target : CHEMBL2185
ChEMBL	Ki	nM	3981.070	CDK7	-	Target : CHEMBL3055
ChEMBL	Ki	nM	19.950	CSF1R	-	Target : CHEMBL1844
ChEMBL	Ki	nM	158.490	FGFR1	-	Target : CHEMBL3650
ChEMBL	Ki	nM	15.850	FLT1	-	Target : CHEMBL1868
ChEMBL	Ki	nM	1995.260	FYN	-	Target : CHEMBL1841
ChEMBL	Ki	nM	1995.260	IGF1R	-	Target : CHEMBL1957
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Ki	nM	3.160	KDR	-	Target : CHEMBL279
ChEMBL	Ki	nM	501.190	LCK	-	Target : CHEMBL258
ChEMBL	Ki	nM	1258.930	LIMK1	-	Target : CHEMBL3836
ChEMBL	Ki	nM	1584.890	LTK	-	Target : CHEMBL5627
ChEMBL	Ki	nM	316.230	MAP4K4	-	Target : CHEMBL6166
ChEMBL	Ki	nM	501.190	MAPK8	-	Target : CHEMBL2276
ChEMBL	Ki	nM	1995.260	MAPK9	-	Target : CHEMBL4179
ChEMBL	Ki	nM	1584.890	MET	-	Target : CHEMBL3717
ChEMBL	Ki	nM	398.110	NEK2	-	Target : CHEMBL3835
ChEMBL	Ki	nM	630.960	PDGFRA	-	Target : CHEMBL2007
ChEMBL	Ki	nM	3.980	PDGFRB	-	Target : CHEMBL1913
ChEMBL	Ki	nM	5011.870	PTK2	-	Target : CHEMBL2695
ChEMBL	Ki	nM	79.430	RET	-	Target : CHEMBL2041
ChEMBL	Ki	nM	794.330	TAOK1	-	Target : CHEMBL5261
ChEMBL	Ki	nM	3162.280	TNK2	-	Target : CHEMBL4599

Download gene sets

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