Drug Gene Type Source mitoxantrone ABCA1 Text_Mining(affects(response to substance)) CTD mitoxantrone ABCB1 Text_Mining(increases(expression)) CTD mitoxantrone ABCG2 Text_Mining(decreases(reaction)) CTD mitoxantrone ABCG2 Text_Mining(increases(export)) CTD mitoxantrone ABCG2 Text_Mining(increases(transport)) CTD mitoxantrone ABCG2 Text_Mining(decreases(response to substance)) CTD mitoxantrone ABCG2 Text_Mining(affects(export)) CTD mitoxantrone ABCG2 Text_Mining(affects(transport)) CTD mitoxantrone ABCG2 Text_Mining(affects(uptake)) CTD mitoxantrone ABCG2 Text_Mining(decreases(abundance)) CTD mitoxantrone ABCG2 Text_Mining(increases(response to substance)) CTD mitoxantrone ABCG2 Text_Mining(increases(secretion)) CTD mitoxantrone ABCG2 Text_Mining(increases(expression)) CTD mitoxantrone ABCG2 Text_Mining(increases(reaction)) CTD mitoxantrone ACSL3 Text_Mining(affects(response to substance)) CTD mitoxantrone ACTG2 Text_Mining(affects(response to substance)) CTD mitoxantrone ADARB1 Text_Mining(affects(response to substance)) CTD mitoxantrone AGPAT5 Text_Mining(affects(response to substance)) CTD mitoxantrone AHCYL1 Text_Mining(affects(response to substance)) CTD mitoxantrone ALDH2 Text_Mining(affects(response to substance)) CTD mitoxantrone AMOTL1 Text_Mining(affects(response to substance)) CTD mitoxantrone APOBEC3C Text_Mining(affects(response to substance)) CTD mitoxantrone ASNS Text_Mining(affects(response to substance)) CTD mitoxantrone ASS1 Text_Mining(affects(response to substance)) CTD mitoxantrone ATP7A Text_Mining(decreases(response to substance)) CTD mitoxantrone BACE2 Text_Mining(affects(response to substance)) CTD mitoxantrone BBX Text_Mining(affects(response to substance)) CTD mitoxantrone BCAM Text_Mining(affects(response to substance)) CTD mitoxantrone BCL2 Text_Mining(decreases(reaction)) CTD mitoxantrone BCL2 Text_Mining(increases(activity)) CTD mitoxantrone BCL2 Text_Mining(increases(degradation)) CTD mitoxantrone BCL2 Text_Mining(affects(cotreatment)) CTD mitoxantrone BCL2 Text_Mining(decreases(expression)) CTD mitoxantrone BCL2L1 Text_Mining(decreases(reaction)) CTD mitoxantrone BCL2L1 Text_Mining(increases(activity)) CTD mitoxantrone BCL2L1 Text_Mining(increases(degradation)) CTD mitoxantrone BIRC2 Text_Mining(decreases(expression)) CTD mitoxantrone BIRC5 Text_Mining(affects(expression)) CTD mitoxantrone BIRC5 Text_Mining(increases(expression)) CTD mitoxantrone BMP7 Text_Mining(affects(response to substance)) CTD mitoxantrone BST2 Text_Mining(affects(response to substance)) CTD mitoxantrone BTBD3 Text_Mining(affects(response to substance)) CTD mitoxantrone C3ORF14 Text_Mining(affects(response to substance)) CTD mitoxantrone CAMK2N1 Text_Mining(affects(response to substance)) CTD mitoxantrone CASC3 Text_Mining(affects(response to substance)) CTD mitoxantrone CASP2 Text_Mining(increases(expression)) CTD mitoxantrone CASP2 Text_Mining(increases(splicing)) CTD mitoxantrone CASP3 Text_Mining(decreases(reaction)) CTD mitoxantrone CASP3 Text_Mining(increases(activity)) CTD mitoxantrone CASP3 Text_Mining(increases(reaction)) CTD mitoxantrone CASP6 Text_Mining(increases(activity)) CTD mitoxantrone CASP7 Text_Mining(increases(activity)) CTD mitoxantrone CASP7 Text_Mining(increases(reaction)) CTD mitoxantrone CASP8 Text_Mining(increases(activity)) CTD mitoxantrone CASP9 Text_Mining(increases(activity)) CTD mitoxantrone CCDC53 Text_Mining(affects(response to substance)) CTD mitoxantrone CD55 Text_Mining(affects(response to substance)) CTD mitoxantrone CD58 Text_Mining(affects(response to substance)) CTD mitoxantrone CELF2 Text_Mining(affects(response to substance)) CTD mitoxantrone CES2 Text_Mining(affects(response to substance)) CTD mitoxantrone CHRDL1 Text_Mining(affects(response to substance)) CTD mitoxantrone CKLF Text_Mining(affects(response to substance)) CTD mitoxantrone CLNS1A Text_Mining(affects(response to substance)) CTD mitoxantrone CLU Text_Mining(affects(response to substance)) CTD mitoxantrone COCH Text_Mining(affects(response to substance)) CTD mitoxantrone COL11A1 Text_Mining(affects(response to substance)) CTD mitoxantrone CPVL Text_Mining(affects(response to substance)) CTD mitoxantrone CREBL2 Text_Mining(affects(response to substance)) CTD mitoxantrone CSRNP2 Text_Mining(affects(response to substance)) CTD mitoxantrone CTH Text_Mining(affects(response to substance)) CTD mitoxantrone CXADR Text_Mining(affects(response to substance)) CTD mitoxantrone DAPK1 Text_Mining(affects(response to substance)) CTD mitoxantrone DDIT4 Text_Mining(affects(response to substance)) CTD mitoxantrone DHRS2 Text_Mining(affects(response to substance)) CTD mitoxantrone DIS3 Text_Mining(affects(response to substance)) CTD mitoxantrone DUSP4 Text_Mining(affects(response to substance)) CTD mitoxantrone DYRK2 Text_Mining(affects(response to substance)) CTD mitoxantrone EGR1 Text_Mining(affects(response to substance)) CTD mitoxantrone EIF2S1 Text_Mining(affects(response to substance)) CTD mitoxantrone EIF5A Text_Mining(affects(response to substance)) CTD mitoxantrone ELAVL4 Text_Mining(affects(response to substance)) CTD mitoxantrone ELOVL5 Text_Mining(affects(response to substance)) CTD mitoxantrone EN2 Text_Mining(affects(response to substance)) CTD mitoxantrone ENC1 Text_Mining(affects(response to substance)) CTD mitoxantrone EPB41L2 Text_Mining(affects(response to substance)) CTD mitoxantrone ERBB2 Text_Mining(decreases(reaction)) CTD mitoxantrone ERBB2 Text_Mining(decreases(response to substance)) CTD mitoxantrone ERBB2 Text_Mining(increases(expression)) CTD mitoxantrone EVI5 Text_Mining(affects(response to substance)) CTD mitoxantrone EXTL2 Text_Mining(affects(response to substance)) CTD mitoxantrone FAM117A Text_Mining(affects(response to substance)) CTD mitoxantrone FAS Text_Mining(increases(expression)) CTD mitoxantrone FAS Text_Mining(increases(reaction)) CTD mitoxantrone FASN Text_Mining(decreases(response to substance)) CTD mitoxantrone FASN Text_Mining(decreases(reaction)) CTD mitoxantrone FDFT1 Text_Mining(affects(response to substance)) CTD mitoxantrone FLRT3 Text_Mining(affects(response to substance)) CTD mitoxantrone FNDC3A Text_Mining(affects(response to substance)) CTD mitoxantrone FOXF2 Text_Mining(affects(response to substance)) CTD mitoxantrone FYN Text_Mining(affects(response to substance)) CTD mitoxantrone FZD2 Text_Mining(affects(response to substance)) CTD mitoxantrone GAGE2A Text_Mining(affects(response to substance)) CTD mitoxantrone GAGE4 Text_Mining(affects(response to substance)) CTD mitoxantrone GAGE6 Text_Mining(affects(response to substance)) CTD mitoxantrone GAGE7 Text_Mining(affects(response to substance)) CTD mitoxantrone GCH1 Text_Mining(affects(response to substance)) CTD mitoxantrone GLUL Text_Mining(affects(response to substance)) CTD mitoxantrone GPX3 Text_Mining(affects(response to substance)) CTD mitoxantrone GUCY1B3 Text_Mining(affects(response to substance)) CTD mitoxantrone HDAC4 Text_Mining(affects(response to substance)) CTD mitoxantrone HLA-DRB5 Text_Mining(affects(response to substance)) CTD mitoxantrone HMG20B Text_Mining(affects(response to substance)) CTD mitoxantrone HOXA5 Text_Mining(affects(response to substance)) CTD mitoxantrone HSPA2 Text_Mining(affects(response to substance)) CTD mitoxantrone IDH3A Text_Mining(affects(response to substance)) CTD mitoxantrone IFITM1 Text_Mining(affects(response to substance)) CTD mitoxantrone IGF1R Text_Mining(affects(response to substance)) CTD mitoxantrone IGF2BP3 Text_Mining(affects(response to substance)) CTD mitoxantrone IGFBP3 Text_Mining(affects(response to substance)) CTD mitoxantrone IGFBP7 Text_Mining(affects(response to substance)) CTD mitoxantrone IL13RA2 Text_Mining(affects(response to substance)) CTD mitoxantrone IQGAP1 Text_Mining(affects(response to substance)) CTD mitoxantrone IRF7 Text_Mining(affects(response to substance)) CTD mitoxantrone IRX1 Text_Mining(affects(response to substance)) CTD mitoxantrone ISG15 Text_Mining(affects(response to substance)) CTD mitoxantrone ISG20 Text_Mining(affects(response to substance)) CTD mitoxantrone JUN Text_Mining(increases(expression)) CTD mitoxantrone JUN Text_Mining(increases(reaction)) CTD mitoxantrone KCNAB2 Text_Mining(affects(response to substance)) CTD mitoxantrone KRR1 Text_Mining(affects(response to substance)) CTD mitoxantrone LAMA2 Text_Mining(affects(response to substance)) CTD mitoxantrone LAMB1 Text_Mining(affects(response to substance)) CTD mitoxantrone LAMC1 Text_Mining(affects(response to substance)) CTD mitoxantrone LBH Text_Mining(affects(response to substance)) CTD mitoxantrone LEMD2 Text_Mining(affects(response to substance)) CTD mitoxantrone LGR4 Text_Mining(affects(response to substance)) CTD mitoxantrone LIPA Text_Mining(affects(response to substance)) CTD mitoxantrone LIPG Text_Mining(affects(response to substance)) CTD mitoxantrone LMNB1 Text_Mining(affects(cotreatment)) CTD mitoxantrone LMNB1 Text_Mining(decreases(expression)) CTD mitoxantrone MACROD1 Text_Mining(affects(response to substance)) CTD mitoxantrone MAFF Text_Mining(affects(response to substance)) CTD mitoxantrone MAGEA6 Text_Mining(affects(response to substance)) CTD mitoxantrone MAGED1 Text_Mining(affects(response to substance)) CTD mitoxantrone MAGED4B Text_Mining(affects(response to substance)) CTD mitoxantrone MDM2 Text_Mining(decreases(response to substance)) CTD mitoxantrone MEST Text_Mining(affects(response to substance)) CTD mitoxantrone MIR654 Text_Mining(increases(response to substance)) CTD mitoxantrone MIR765 Text_Mining(increases(response to substance)) CTD mitoxantrone MOCOS Text_Mining(affects(response to substance)) CTD mitoxantrone MPC2 Text_Mining(affects(response to substance)) CTD mitoxantrone MTHFD2 Text_Mining(affects(response to substance)) CTD mitoxantrone MXI1 Text_Mining(affects(response to substance)) CTD mitoxantrone MYC Text_Mining(decreases(expression)) CTD mitoxantrone MYC Text_Mining(increases(reaction)) CTD mitoxantrone MYCBP2 Text_Mining(affects(response to substance)) CTD mitoxantrone NAMPT Text_Mining(affects(response to substance)) CTD mitoxantrone NDUFS5 Text_Mining(affects(response to substance)) CTD mitoxantrone NEFH Text_Mining(affects(response to substance)) CTD mitoxantrone NID2 Text_Mining(affects(response to substance)) CTD mitoxantrone NR3C1 Text_Mining(decreases(activity)) CTD mitoxantrone NR4A2 Text_Mining(affects(response to substance)) CTD mitoxantrone NRIP1 Text_Mining(affects(response to substance)) CTD mitoxantrone OXCT1 Text_Mining(affects(response to substance)) CTD mitoxantrone P4HA1 Text_Mining(affects(response to substance)) CTD mitoxantrone PACRGL Text_Mining(affects(response to substance)) CTD mitoxantrone PARP1 Text_Mining(decreases(reaction)) CTD mitoxantrone PARP1 Text_Mining(increases(degradation)) CTD mitoxantrone PARP1 Text_Mining(affects(cotreatment)) CTD mitoxantrone PARP1 Text_Mining(decreases(expression)) CTD mitoxantrone PBX1 Text_Mining(affects(response to substance)) CTD mitoxantrone PDE4D Text_Mining(affects(response to substance)) CTD mitoxantrone PDE8A Text_Mining(affects(response to substance)) CTD mitoxantrone PHGDH Text_Mining(affects(response to substance)) CTD mitoxantrone PLAGL1 Text_Mining(affects(response to substance)) CTD mitoxantrone PLAT Text_Mining(affects(response to substance)) CTD mitoxantrone PLCB4 Text_Mining(affects(response to substance)) CTD mitoxantrone PML Text_Mining(affects(mutagenesis)) CTD mitoxantrone POMZP3 Text_Mining(affects(response to substance)) CTD mitoxantrone PPP1R2 Text_Mining(affects(response to substance)) CTD mitoxantrone PRDX2 Text_Mining(affects(response to substance)) CTD mitoxantrone PRKCDBP Text_Mining(affects(response to substance)) CTD mitoxantrone PROSC Text_Mining(affects(response to substance)) CTD mitoxantrone PTPRE Text_Mining(affects(response to substance)) CTD mitoxantrone RARA Text_Mining(affects(mutagenesis)) CTD mitoxantrone RARB Text_Mining(increases(expression)) CTD mitoxantrone RASA1 Text_Mining(affects(response to substance)) CTD mitoxantrone RBBP8 Text_Mining(affects(response to substance)) CTD mitoxantrone RBM17 Text_Mining(decreases(reaction)) CTD mitoxantrone RBM17 Text_Mining(decreases(response to substance)) CTD mitoxantrone RCBTB1 Text_Mining(affects(response to substance)) CTD mitoxantrone RCHY1 Text_Mining(affects(response to substance)) CTD mitoxantrone RGS2 Text_Mining(affects(response to substance)) CTD mitoxantrone RRAGD Text_Mining(affects(response to substance)) CTD mitoxantrone RUNX3 Text_Mining(affects(response to substance)) CTD mitoxantrone S100P Text_Mining(affects(response to substance)) CTD mitoxantrone SALL2 Text_Mining(affects(response to substance)) CTD mitoxantrone SATB2 Text_Mining(affects(response to substance)) CTD mitoxantrone SCD Text_Mining(affects(response to substance)) CTD mitoxantrone SCHIP1 Text_Mining(affects(response to substance)) CTD mitoxantrone SDC2 Text_Mining(affects(response to substance)) CTD mitoxantrone SEC31A Text_Mining(affects(response to substance)) CTD mitoxantrone SFN Text_Mining(affects(response to substance)) CTD mitoxantrone SFRP4 Text_Mining(affects(response to substance)) CTD mitoxantrone SLC16A6 Text_Mining(affects(response to substance)) CTD mitoxantrone SLC7A5 Text_Mining(affects(response to substance)) CTD mitoxantrone SLCO4A1 Text_Mining(affects(response to substance)) CTD mitoxantrone SLMO2 Text_Mining(affects(response to substance)) CTD mitoxantrone SMAD2 Text_Mining(affects(response to substance)) CTD mitoxantrone SORBS1 Text_Mining(affects(response to substance)) CTD mitoxantrone SPON1 Text_Mining(affects(response to substance)) CTD mitoxantrone SPON2 Text_Mining(affects(response to substance)) CTD mitoxantrone SRD5A1 Text_Mining(affects(response to substance)) CTD mitoxantrone SYTL2 Text_Mining(affects(response to substance)) CTD mitoxantrone TAGLN Text_Mining(affects(response to substance)) CTD mitoxantrone TAP1 Text_Mining(affects(response to substance)) CTD mitoxantrone TBC1D8 Text_Mining(affects(response to substance)) CTD mitoxantrone TFF3 Text_Mining(affects(response to substance)) CTD mitoxantrone TIA1 Text_Mining(affects(response to substance)) CTD mitoxantrone TMEM47 Text_Mining(affects(response to substance)) CTD mitoxantrone TMEM99 Text_Mining(affects(response to substance)) CTD mitoxantrone TNKS Text_Mining(affects(response to substance)) CTD mitoxantrone TPD52 Text_Mining(affects(response to substance)) CTD mitoxantrone TPM1 Text_Mining(affects(response to substance)) CTD mitoxantrone TRIB1 Text_Mining(affects(response to substance)) CTD mitoxantrone TRIM2 Text_Mining(affects(response to substance)) CTD mitoxantrone UBL3 Text_Mining(affects(response to substance)) CTD mitoxantrone UCHL1 Text_Mining(affects(response to substance)) CTD mitoxantrone UQCRH Text_Mining(affects(response to substance)) CTD mitoxantrone UTRN Text_Mining(affects(response to substance)) CTD mitoxantrone VCAN Text_Mining(affects(response to substance)) CTD mitoxantrone WARS Text_Mining(affects(response to substance)) CTD mitoxantrone XIAP Text_Mining(affects(localization)) CTD mitoxantrone XIAP Text_Mining(decreases(expression)) CTD mitoxantrone ZFAND1 Text_Mining(affects(response to substance)) CTD mitoxantrone ZSCAN18 Text_Mining(affects(response to substance)) CTD mitoxantrone APEX1 Potency=7943.3(nM) D4 ChEMBL mitoxantrone ARNT None=None(uM) D4 PubChem mitoxantrone ARSA Potency=23.9341(uM) D4 PubChem mitoxantrone ATAD5 Potency=4.609(uM) D4 PubChem mitoxantrone ATAD5 Potency=4609.0(nM) D4 ChEMBL mitoxantrone ATXN2 Potency=2.9935(uM) D4 PubChem mitoxantrone BLM Potency=1.358(uM) D4 PubChem mitoxantrone BLM Potency=14.1254(uM) D4 PubChem mitoxantrone BLM Potency=14125.4(nM) D4 ChEMBL mitoxantrone CBX1 Potency=5.6234(uM) D4 PubChem mitoxantrone CBX1 Potency=25.1189(uM) D4 PubChem mitoxantrone CBX1 Potency=5623.4(nM) D4 ChEMBL mitoxantrone COPS5 None=None(uM) D4 PubChem mitoxantrone CYP1A2 None=None(uM) D4 PubChem mitoxantrone CYP3A4 Potency=25.1189(uM) D4 PubChem mitoxantrone CYP3A4 Potency=25118.9(nM) D4 ChEMBL mitoxantrone EHMT2 Potency=3.9811(uM) D4 PubChem mitoxantrone EHMT2 Potency=8.4368(uM) D4 PubChem mitoxantrone EHMT2 Potency=3981.1(nM) D4 ChEMBL mitoxantrone EHMT2 Potency=8436.8(nM) D4 ChEMBL mitoxantrone EPAS1 None=None(uM) D4 PubChem mitoxantrone ERAP1 None=None(uM) D4 PubChem mitoxantrone FEN1 Potency=1.3459(uM) D4 PubChem mitoxantrone FEN1 Potency=2.8184(uM) D4 PubChem mitoxantrone FEN1 Potency=2.9935(uM) D4 PubChem mitoxantrone FEN1 Potency=2993.5(nM) D4 ChEMBL mitoxantrone GLS Potency=3.5481(uM) D4 PubChem mitoxantrone HTT Potency=10.0(uM) D4 PubChem mitoxantrone HTT Potency=10000.0(nM) D4 ChEMBL mitoxantrone IL1B None=None(uM) D4 PubChem mitoxantrone KDM4A Potency=6309.6(nM) D4 ChEMBL mitoxantrone MAPK1 Potency=3.9811(uM) D4 PubChem mitoxantrone MAPK1 Potency=3981.1(nM) D4 ChEMBL mitoxantrone MAPT None=None(uM) D4 PubChem mitoxantrone MBD2 None=None(uM) D4 PubChem mitoxantrone MBNL1 Potency=0.8784(uM) D4 PubChem mitoxantrone MBNL1 Potency=878.4(nM) D4 ChEMBL mitoxantrone MITF None=None(uM) D4 PubChem mitoxantrone MLLT3 AC50_uM=0.374(uM) D4 PubChem mitoxantrone MLLT3 None=None(uM) D4 PubChem mitoxantrone MMP2 None=None(uM) D4 PubChem mitoxantrone MPHOSPH8 Potency=6.7016(uM) D4 PubChem mitoxantrone MPHOSPH8 Potency=6701.6(nM) D4 ChEMBL mitoxantrone NCOA1 None=None(uM) D4 PubChem mitoxantrone NFKB1 Potency=1.9953(uM) D4 PubChem mitoxantrone NFKB1 Potency=1995.3(nM) D4 ChEMBL mitoxantrone PIM1 Inhibition=None(Unspecified) D4 ChEMBL mitoxantrone PLA2G3 None=None(uM) D4 PubChem mitoxantrone POLH Potency=3.1623(uM) D4 PubChem mitoxantrone POLH Potency=19.0115(uM) D4 PubChem mitoxantrone POLI Potency=2.9935(uM) D4 PubChem mitoxantrone POLI Potency=11.2202(uM) D4 PubChem mitoxantrone POLK Potency=1.3371(uM) D4 PubChem mitoxantrone POLK Potency=2.3778(uM) D4 PubChem mitoxantrone POLK Potency=2.6679(uM) D4 PubChem mitoxantrone POLK Potency=25.1189(uM) D4 PubChem mitoxantrone PSIP1 None=None(uM) D4 PubChem mitoxantrone PSMD14 None=None(uM) D4 PubChem mitoxantrone RACGAP1 IC50=14.46(uM) D4 PubChem mitoxantrone RAD52 AC50_uM=0.244(uM) D4 PubChem mitoxantrone RAD52 None=None(uM) D4 PubChem mitoxantrone RBBP8 None=None(uM) D4 PubChem mitoxantrone RECQL Potency=12589.3(nM) D4 ChEMBL mitoxantrone RECQL Potency=28183.8(nM) D4 ChEMBL mitoxantrone RGS4 Potency=11.9173(uM) D4 PubChem mitoxantrone SENP8 None=None(uM) D4 PubChem mitoxantrone SIX1 None=None(uM) D4 PubChem mitoxantrone SMAD3 Potency=1.5849(uM) D4 PubChem mitoxantrone STK33 None=None(uM) D4 PubChem mitoxantrone SUMO1 None=None(uM) D4 PubChem mitoxantrone TACC3 None=None(uM) D4 PubChem mitoxantrone TDP1 Potency=0.0326(uM) D4 PubChem mitoxantrone TDP1 Potency=0.1836(uM) D4 PubChem mitoxantrone THPO Potency=0.0251(uM) D4 PubChem mitoxantrone THPO Potency=25.1(nM) D4 ChEMBL mitoxantrone TNFRSF10B None=None(uM) D4 PubChem mitoxantrone TP53 Potency=15.8489(uM) D4 PubChem mitoxantrone TP53 Potency=15848.9(nM) D4 ChEMBL mitoxantrone UHRF1 None=None(uM) D4 PubChem mitoxantrone WHSC1 AC50_uM=2.34(uM) D4 PubChem mitoxantrone WHSC1 None=None(uM) D4 PubChem mitoxantrone WRN Potency=0.9614(uM) D4 PubChem mitoxantrone WRN Potency=8.9125(uM) D4 PubChem mitoxantrone YES1 Potency=34.4993(uM) D4 PubChem