Drug Gene Type Source camptothecin ABCB1 Text_Mining(decreases(expression)) CTD camptothecin ABCC1 Text_Mining(decreases(response to substance)) CTD camptothecin ABCC1 Text_Mining(decreases(reaction)) CTD camptothecin AGRN Text_Mining(increases(expression)) CTD camptothecin AKT1 Text_Mining(affects(phosphorylation)) CTD camptothecin AKT1 Text_Mining(affects(reaction)) CTD camptothecin ALB Text_Mining(affects(binding)) CTD camptothecin ALB Text_Mining(increases(cleavage)) CTD camptothecin ANXA4 Text_Mining(increases(expression)) CTD camptothecin ATG5 Text_Mining(decreases(reaction)) CTD camptothecin ATG5 Text_Mining(increases(degradation)) CTD camptothecin ATM Text_Mining(decreases(expression)) CTD camptothecin BAX Text_Mining(affects(cleavage)) CTD camptothecin BAX Text_Mining(decreases(expression)) CTD camptothecin BAX Text_Mining(affects(cotreatment)) CTD camptothecin BAX Text_Mining(increases(activity)) CTD camptothecin BAX Text_Mining(increases(expression)) CTD camptothecin BCL2 Text_Mining(decreases(expression)) CTD camptothecin BCL2 Text_Mining(increases(reaction)) CTD camptothecin BCL2 Text_Mining(decreases(response to substance)) CTD camptothecin BCL2 Text_Mining(increases(expression)) CTD camptothecin BID Text_Mining(affects(cotreatment)) CTD camptothecin BID Text_Mining(decreases(expression)) CTD camptothecin BID Text_Mining(increases(cleavage)) CTD camptothecin BIRC5 Text_Mining(affects(cotreatment)) CTD camptothecin BIRC5 Text_Mining(decreases(expression)) CTD camptothecin BIRC5 Text_Mining(increases(expression)) CTD camptothecin BRCA1 Text_Mining(decreases(expression)) CTD camptothecin BRCA2 Text_Mining(decreases(expression)) CTD camptothecin CAB39 Text_Mining(decreases(expression)) CTD camptothecin CASP2 Text_Mining(increases(expression)) CTD camptothecin CASP2 Text_Mining(increases(splicing)) CTD camptothecin CASP3 Text_Mining(increases(activity)) CTD camptothecin CASP3 Text_Mining(increases(reaction)) CTD camptothecin CASP3 Text_Mining(decreases(reaction)) CTD camptothecin CASP3 Text_Mining(affects(cotreatment)) CTD camptothecin CASP3 Text_Mining(increases(cleavage)) CTD camptothecin CASP3 Text_Mining(affects(reaction)) CTD camptothecin CASP7 Text_Mining(decreases(reaction)) CTD camptothecin CASP7 Text_Mining(increases(activity)) CTD camptothecin CASP7 Text_Mining(increases(reaction)) CTD camptothecin CASP8 Text_Mining(decreases(reaction)) CTD camptothecin CASP8 Text_Mining(increases(activity)) CTD camptothecin CASP8 Text_Mining(affects(cleavage)) CTD camptothecin CASP8 Text_Mining(affects(cotreatment)) CTD camptothecin CASP8 Text_Mining(increases(cleavage)) CTD camptothecin CASP9 Text_Mining(affects(cotreatment)) CTD camptothecin CASP9 Text_Mining(increases(activity)) CTD camptothecin CASP9 Text_Mining(increases(cleavage)) CTD camptothecin CCL2 Text_Mining(decreases(expression)) CTD camptothecin CCL4 Text_Mining(decreases(expression)) CTD camptothecin CCL5 Text_Mining(decreases(expression)) CTD camptothecin CCNB1 Text_Mining(affects(cotreatment)) CTD camptothecin CCNB1 Text_Mining(decreases(expression)) CTD camptothecin CDK2 Text_Mining(decreases(activity)) CTD camptothecin CDK2 Text_Mining(increases(phosphorylation)) CTD camptothecin CDKN1A Text_Mining(decreases(reaction)) CTD camptothecin CDKN1A Text_Mining(increases(expression)) CTD camptothecin CEACAM1 Text_Mining(increases(expression)) CTD camptothecin CEBPZ Text_Mining(decreases(expression)) CTD camptothecin CLPTM1L Text_Mining(increases(response to substance)) CTD camptothecin CTSB Text_Mining(affects(binding)) CTD camptothecin CTSB Text_Mining(increases(cleavage)) CTD camptothecin CXCL8 Text_Mining(decreases(expression)) CTD camptothecin CXCL8 Text_Mining(increases(secretion)) CTD camptothecin CXCL8 Text_Mining(decreases(reaction)) CTD camptothecin CXCL8 Text_Mining(decreases(response to substance)) CTD camptothecin CYCS Text_Mining(affects(localization)) CTD camptothecin CYCS Text_Mining(increases(reaction)) CTD camptothecin DPYD Text_Mining(decreases(reaction)) CTD camptothecin DPYD Text_Mining(increases(expression)) CTD camptothecin DPYD Text_Mining(decreases(activity)) CTD camptothecin DPYD Text_Mining(decreases(expression)) CTD camptothecin EI24 Text_Mining(increases(expression)) CTD camptothecin EP300 Text_Mining(decreases(expression)) CTD camptothecin EPM2AIP1 Text_Mining(increases(expression)) CTD camptothecin ERCC1 Text_Mining(decreases(expression)) CTD camptothecin ERCC1 Text_Mining(increases(expression)) CTD camptothecin ERCC1 Text_Mining(increases(reaction)) CTD camptothecin ERCC4 Text_Mining(increases(expression)) CTD camptothecin ERCC4 Text_Mining(increases(reaction)) CTD camptothecin ERCC4 Text_Mining(decreases(response to substance)) CTD camptothecin FAS Text_Mining(affects(localization)) CTD camptothecin FAS Text_Mining(decreases(reaction)) CTD camptothecin FAS Text_Mining(increases(expression)) CTD camptothecin FAS Text_Mining(affects(cotreatment)) CTD camptothecin FAS Text_Mining(decreases(expression)) CTD camptothecin FAS Text_Mining(increases(activity)) CTD camptothecin FAS Text_Mining(increases(cleavage)) CTD camptothecin FDXR Text_Mining(increases(expression)) CTD camptothecin FXN Text_Mining(increases(expression)) CTD camptothecin GADD45A Text_Mining(decreases(expression)) CTD camptothecin GADD45G Text_Mining(increases(expression)) CTD camptothecin GSTP1 Text_Mining(increases(expression)) CTD camptothecin GSTP1 Text_Mining(decreases(response to substance)) CTD camptothecin H2AFX Text_Mining(increases(expression)) CTD camptothecin H2AFX Text_Mining(increases(reaction)) CTD camptothecin H2AFX Text_Mining(decreases(reaction)) CTD camptothecin H2AFX Text_Mining(increases(response to substance)) CTD camptothecin H2AFX Text_Mining(decreases(expression)) CTD camptothecin HNRNPC Text_Mining(affects(binding)) CTD camptothecin HNRNPC Text_Mining(decreases(response to substance)) CTD camptothecin IL1B Text_Mining(decreases(response to substance)) CTD camptothecin IL6R Text_Mining(decreases(expression)) CTD camptothecin JUN Text_Mining(increases(expression)) CTD camptothecin JUN Text_Mining(increases(phosphorylation)) CTD camptothecin LGALS1 Text_Mining(decreases(expression)) CTD camptothecin MAP2K3 Text_Mining(increases(expression)) CTD camptothecin MAP3K5 Text_Mining(decreases(expression)) CTD camptothecin MAPK1 Text_Mining(affects(cotreatment)) CTD camptothecin MAPK1 Text_Mining(increases(phosphorylation)) CTD camptothecin MAPK3 Text_Mining(affects(cotreatment)) CTD camptothecin MAPK3 Text_Mining(increases(phosphorylation)) CTD camptothecin MAPK9 Text_Mining(increases(phosphorylation)) CTD camptothecin MAPT Text_Mining(decreases(expression)) CTD camptothecin MDM2 Text_Mining(increases(expression)) CTD camptothecin MGMT Text_Mining(decreases(expression)) CTD camptothecin MIR138-1 Text_Mining(decreases(reaction)) CTD camptothecin MIR138-1 Text_Mining(increases(response to substance)) CTD camptothecin MIR138-1 Text_Mining(decreases(expression)) CTD camptothecin MIR145 Text_Mining(decreases(expression)) CTD camptothecin MIR145 Text_Mining(increases(expression)) CTD camptothecin MIR15A Text_Mining(decreases(expression)) CTD camptothecin MIR15A Text_Mining(increases(expression)) CTD camptothecin MIR34A Text_Mining(increases(expression)) CTD camptothecin MRE11A Text_Mining(decreases(expression)) CTD camptothecin NCK2 Text_Mining(decreases(expression)) CTD camptothecin PARP1 Text_Mining(decreases(reaction)) CTD camptothecin PARP1 Text_Mining(increases(cleavage)) CTD camptothecin PARP1 Text_Mining(increases(reaction)) CTD camptothecin PLK3 Text_Mining(increases(expression)) CTD camptothecin PPP1R1B Text_Mining(decreases(response to substance)) CTD camptothecin PRC1 Text_Mining(decreases(expression)) CTD camptothecin RAD50 Text_Mining(decreases(expression)) CTD camptothecin RAD51 Text_Mining(decreases(expression)) CTD camptothecin RAD51C Text_Mining(increases(response to substance)) CTD camptothecin RB1 Text_Mining(increases(phosphorylation)) CTD camptothecin RB1 Text_Mining(affects(response to substance)) CTD camptothecin RBL1 Text_Mining(decreases(expression)) CTD camptothecin RBL2 Text_Mining(decreases(reaction)) CTD camptothecin RBL2 Text_Mining(increases(cleavage)) CTD camptothecin RBL2 Text_Mining(decreases(response to substance)) CTD camptothecin RELA Text_Mining(increases(response to substance)) CTD camptothecin SDC1 Text_Mining(increases(expression)) CTD camptothecin SIRT1 Text_Mining(decreases(reaction)) CTD camptothecin SIRT1 Text_Mining(increases(expression)) CTD camptothecin SIRT1 Text_Mining(decreases(expression)) CTD camptothecin SIRT1 Text_Mining(affects(cotreatment)) CTD camptothecin SIRT1 Text_Mining(increases(acetylation)) CTD camptothecin SMN1 Text_Mining(affects(reaction)) CTD camptothecin SMN1 Text_Mining(increases(activity)) CTD camptothecin SMN1 Text_Mining(increases(response to substance)) CTD camptothecin SMPD3 Text_Mining(increases(expression)) CTD camptothecin SP1 Text_Mining(increases(activity)) CTD camptothecin SP1 Text_Mining(decreases(reaction)) CTD camptothecin SP3 Text_Mining(increases(activity)) CTD camptothecin SP3 Text_Mining(decreases(reaction)) CTD camptothecin SQSTM1 Text_Mining(decreases(reaction)) CTD camptothecin SQSTM1 Text_Mining(increases(degradation)) CTD camptothecin TAP1 Text_Mining(increases(expression)) CTD camptothecin TAX1BP3 Text_Mining(increases(expression)) CTD camptothecin TDP1 Text_Mining(decreases(reaction)) CTD camptothecin TDP1 Text_Mining(increases(expression)) CTD camptothecin TDP1 Text_Mining(increases(reaction)) CTD camptothecin THBS1 Text_Mining(decreases(expression)) CTD camptothecin THBS1 Text_Mining(decreases(secretion)) CTD camptothecin THBS1 Text_Mining(decreases(reaction)) CTD camptothecin THBS1 Text_Mining(increases(activity)) CTD camptothecin THBS1 Text_Mining(increases(cleavage)) CTD camptothecin TNFSF9 Text_Mining(increases(expression)) CTD camptothecin TOP1 Text_Mining(decreases(activity)) CTD camptothecin TOP1 Text_Mining(affects(cotreatment)) CTD camptothecin TOP1 Text_Mining(decreases(response to substance)) CTD camptothecin TP53 Text_Mining(increases(expression)) CTD camptothecin TP53 Text_Mining(increases(reaction)) CTD camptothecin TP53 Text_Mining(decreases(reaction)) CTD camptothecin TP53 Text_Mining(increases(acetylation)) CTD camptothecin TP53 Text_Mining(decreases(acetylation)) CTD camptothecin TP53 Text_Mining(increases(glutathionylation)) CTD camptothecin TP53 Text_Mining(increases(phosphorylation)) CTD camptothecin TP53 Text_Mining(increases(activity)) CTD camptothecin TP53 Text_Mining(increases(stability)) CTD camptothecin TP53 Text_Mining(affects(cotreatment)) CTD camptothecin TP53 Text_Mining(decreases(response to substance)) CTD camptothecin TP53 Text_Mining(increases(response to substance)) CTD camptothecin TP53I3 Text_Mining(increases(expression)) CTD camptothecin TP53TG1 Text_Mining(increases(expression)) CTD camptothecin TYMS Text_Mining(increases(expression)) CTD camptothecin VEGFA Text_Mining(decreases(expression)) CTD camptothecin VEGFA Text_Mining(decreases(response to substance)) CTD camptothecin XIAP Text_Mining(affects(cotreatment)) CTD camptothecin XIAP Text_Mining(decreases(expression)) CTD camptothecin XIAP Text_Mining(decreases(response to substance)) CTD camptothecin XRCC3 Text_Mining(decreases(expression)) CTD camptothecin XRCC4 Text_Mining(decreases(response to substance)) CTD camptothecin ATAD5 Potency=0.4609(uM) D4 PubChem camptothecin ATAD5 Potency=460.9(nM) D4 ChEMBL camptothecin ATXN2 Potency=0.01(uM) D4 PubChem camptothecin CYP1A2 None=None(uM) D4 PubChem camptothecin CYP1A2 AC50=2511.89(nM) D4 ChEMBL camptothecin CYP2C19 Potency=19.9526(uM) D4 PubChem camptothecin CYP2C19 None=None(uM) D4 PubChem camptothecin CYP2C19 AC50=19952.6(nM) D4 ChEMBL camptothecin CYP2C19 Potency=19952.6(nM) D4 ChEMBL camptothecin CYP3A4 Potency=6.3096(uM) D4 PubChem camptothecin CYP3A4 None=None(uM) D4 PubChem camptothecin CYP3A4 Potency=6309.6(nM) D4 ChEMBL camptothecin CYP3A4 AC50=6309.57(nM) D4 ChEMBL camptothecin EHMT2 Potency=44.6684(uM) D4 PubChem camptothecin EHMT2 Potency=44668.4(nM) D4 ChEMBL camptothecin EIF2AK3 None=None(uM) D4 PubChem camptothecin HBB Potency=1.0(uM) D4 PubChem camptothecin HBB Potency=1000.0(nM) D4 ChEMBL camptothecin HIF1A Potency=0.0794(uM) D4 PubChem camptothecin HIF1A Potency=79.4(nM) D4 ChEMBL camptothecin HNRNPA1 Inhibition=None(Unspecified) D4 ChEMBL camptothecin HSD17B10 Potency=7943.3(nM) D4 ChEMBL camptothecin HSD17B10 Potency=10000.0(nM) D4 ChEMBL camptothecin HSD17B10 Potency=3162.3(nM) D4 ChEMBL camptothecin HSD17B10 Potency=3981.1(nM) D4 ChEMBL camptothecin JAK2 None=None(uM) D4 PubChem camptothecin KLF5 None=None(uM) D4 PubChem camptothecin MCL1 Inhibition=None(Unspecified) D4 ChEMBL camptothecin MTOR Potency=0.104(uM) D4 PubChem camptothecin MTOR Potency=104.0(nM) D4 ChEMBL camptothecin NFE2L2 Potency=0.4611(uM) D4 PubChem camptothecin NFE2L2 Potency=2.0596(uM) D4 PubChem camptothecin NFE2L2 Potency=2059.6(nM) D4 ChEMBL camptothecin NOD1 EC50=None(uM) D4 PubChem camptothecin NOD2 EC50=None(uM) D4 PubChem camptothecin S1PR3 None=None(uM) D4 PubChem camptothecin TDP1 Potency=0.0184(uM) D4 PubChem camptothecin TDP1 Potency=0.0335(uM) D4 PubChem camptothecin TDP1 Potency=0.0376(uM) D4 PubChem camptothecin TDP1 Potency=0.0794(uM) D4 PubChem camptothecin TDP1 Potency=0.0891(uM) D4 PubChem camptothecin THPO Potency=0.1259(uM) D4 PubChem camptothecin THPO Potency=125.9(nM) D4 ChEMBL camptothecin TNF None=None(uM) D4 PubChem camptothecin TOP1 Inhibition=None(Unspecified) D4 ChEMBL camptothecin TOP1 IC50=None(Unspecified) D4 ChEMBL camptothecin TOP1 Activity=None(Unspecified) D4 ChEMBL camptothecin TOP1 DNA cleavage=None(Unspecified) D4 ChEMBL