Drug Gene Type Source Silybin AKR1C3 Text_Mining(decreases(activity)) CTD Silybin ATM Text_Mining(increases(activity)) CTD Silybin ATM Text_Mining(increases(phosphorylation)) CTD Silybin BAX Text_Mining(affects(localization)) CTD Silybin BAX Text_Mining(decreases(reaction)) CTD Silybin BCL2 Text_Mining(affects(cotreatment)) CTD Silybin BCL2 Text_Mining(decreases(expression)) CTD Silybin BCL2 Text_Mining(affects(expression)) CTD Silybin BCL2 Text_Mining(decreases(reaction)) CTD Silybin BID Text_Mining(decreases(reaction)) CTD Silybin BID Text_Mining(increases(cleavage)) CTD Silybin BID Text_Mining(affects(localization)) CTD Silybin BIRC5 Text_Mining(affects(cotreatment)) CTD Silybin BIRC5 Text_Mining(decreases(expression)) CTD Silybin CA9 Text_Mining(decreases(expression)) CTD Silybin CA9 Text_Mining(increases(reaction)) CTD Silybin CASP2 Text_Mining(decreases(reaction)) CTD Silybin CASP2 Text_Mining(increases(activity)) CTD Silybin CASP2 Text_Mining(increases(cleavage)) CTD Silybin CASP3 Text_Mining(increases(activity)) CTD Silybin CASP3 Text_Mining(increases(reaction)) CTD Silybin CASP3 Text_Mining(decreases(reaction)) CTD Silybin CASP3 Text_Mining(increases(cleavage)) CTD Silybin CASP3 Text_Mining(increases(expression)) CTD Silybin CASP8 Text_Mining(decreases(reaction)) CTD Silybin CASP8 Text_Mining(increases(activity)) CTD Silybin CASP8 Text_Mining(increases(cleavage)) CTD Silybin CASP9 Text_Mining(decreases(reaction)) CTD Silybin CASP9 Text_Mining(increases(activity)) CTD Silybin CASP9 Text_Mining(increases(cleavage)) CTD Silybin CDKN1A Text_Mining(decreases(reaction)) CTD Silybin CDKN1A Text_Mining(increases(cleavage)) CTD Silybin CHEK2 Text_Mining(decreases(reaction)) CTD Silybin CHEK2 Text_Mining(increases(phosphorylation)) CTD Silybin CTSB Text_Mining(affects(cotreatment)) CTD Silybin CTSB Text_Mining(decreases(expression)) CTD Silybin CXCL8 Text_Mining(decreases(reaction)) CTD Silybin CXCL8 Text_Mining(increases(secretion)) CTD Silybin CYP2C9 Text_Mining(decreases(activity)) CTD Silybin CYP3A4 Text_Mining(decreases(reaction)) CTD Silybin CYP3A4 Text_Mining(increases(hydroxylation)) CTD Silybin CYP3A4 Text_Mining(decreases(activity)) CTD Silybin DDIT3 Text_Mining(affects(reaction)) CTD Silybin DDIT3 Text_Mining(increases(expression)) CTD Silybin EGR1 Text_Mining(decreases(reaction)) CTD Silybin EGR1 Text_Mining(increases(expression)) CTD Silybin ESR1 Text_Mining(affects(binding)) CTD Silybin ESR1 Text_Mining(increases(activity)) CTD Silybin ESR2 Text_Mining(affects(binding)) CTD Silybin ESR2 Text_Mining(increases(activity)) CTD Silybin GDF15 Text_Mining(increases(expression)) CTD Silybin GDF15 Text_Mining(increases(reaction)) CTD Silybin GDF15 Text_Mining(decreases(reaction)) CTD Silybin GDF15 Text_Mining(increases(cleavage)) CTD Silybin H2AFX Text_Mining(decreases(reaction)) CTD Silybin H2AFX Text_Mining(increases(phosphorylation)) CTD Silybin MAPK8 Text_Mining(decreases(reaction)) CTD Silybin MAPK8 Text_Mining(increases(phosphorylation)) CTD Silybin MAPK9 Text_Mining(decreases(reaction)) CTD Silybin MAPK9 Text_Mining(increases(phosphorylation)) CTD Silybin MGMT Text_Mining(increases(activity)) CTD Silybin MGMT Text_Mining(increases(expression)) CTD Silybin MMP14 Text_Mining(affects(cotreatment)) CTD Silybin MMP14 Text_Mining(decreases(expression)) CTD Silybin MMP14 Text_Mining(decreases(reaction)) CTD Silybin MMP14 Text_Mining(increases(expression)) CTD Silybin MMP2 Text_Mining(affects(cotreatment)) CTD Silybin MMP2 Text_Mining(decreases(activity)) CTD Silybin MMP2 Text_Mining(decreases(expression)) CTD Silybin MMP2 Text_Mining(increases(reaction)) CTD Silybin MMP2 Text_Mining(increases(expression)) CTD Silybin MMP9 Text_Mining(affects(cotreatment)) CTD Silybin MMP9 Text_Mining(decreases(expression)) CTD Silybin MMP9 Text_Mining(decreases(activity)) CTD Silybin PARP1 Text_Mining(decreases(reaction)) CTD Silybin PARP1 Text_Mining(increases(cleavage)) CTD Silybin PARP1 Text_Mining(increases(activity)) CTD Silybin PLAU Text_Mining(decreases(expression)) CTD Silybin PLAU Text_Mining(increases(reaction)) CTD Silybin PLAU Text_Mining(affects(cotreatment)) CTD Silybin SLC16A1 Text_Mining(decreases(reaction)) CTD Silybin SLC16A1 Text_Mining(increases(uptake)) CTD Silybin TNFRSF10B Text_Mining(affects(reaction)) CTD Silybin TNFRSF10B Text_Mining(increases(expression)) CTD Silybin TP53 Text_Mining(decreases(reaction)) CTD Silybin TP53 Text_Mining(increases(phosphorylation)) CTD Silybin TP53 Text_Mining(affects(localization)) CTD Silybin TP53 Text_Mining(increases(expression)) CTD Silybin UGT1A1 Text_Mining(decreases(reaction)) CTD Silybin UGT1A1 Text_Mining(increases(glucuronidation)) CTD Silybin UGT1A6 Text_Mining(decreases(reaction)) CTD Silybin UGT1A6 Text_Mining(increases(glucuronidation)) CTD Silybin UGT1A9 Text_Mining(decreases(reaction)) CTD Silybin UGT1A9 Text_Mining(increases(glucuronidation)) CTD Silybin UGT2B15 Text_Mining(decreases(reaction)) CTD Silybin UGT2B15 Text_Mining(increases(glucuronidation)) CTD Silybin UGT2B7 Text_Mining(decreases(reaction)) CTD Silybin UGT2B7 Text_Mining(increases(glucuronidation)) CTD Silybin ABCB11 Text_Mining(decreases(reaction)) CTD Silybin ABCB11 Text_Mining(increases(transport)) CTD Silybin ABCB11 Text_Mining(decreases(activity)) CTD Silybin ABCC1 Text_Mining(decreases(reaction)) CTD Silybin ABCC1 Text_Mining(decreases(response to substance)) CTD Silybin ABCC1 Text_Mining(increases(export)) CTD Silybin ABCC1 Text_Mining(increases(hydrolysis)) CTD Silybin ABCC4 Text_Mining(decreases(reaction)) CTD Silybin ABCC4 Text_Mining(increases(export)) CTD Silybin ABCC4 Text_Mining(increases(hydrolysis)) CTD Silybin ABCC4 Text_Mining(increases(reaction)) CTD Silybin ABCC5 Text_Mining(decreases(reaction)) CTD Silybin ABCC5 Text_Mining(increases(export)) CTD Silybin ABCG2 Text_Mining(increases(expression)) CTD Silybin ABCG2 Text_Mining(increases(reaction)) CTD Silybin AHR Text_Mining(increases(expression)) CTD Silybin AHR Text_Mining(increases(reaction)) CTD Silybin ALB Text_Mining(decreases(reaction)) CTD Silybin ALB Text_Mining(decreases(secretion)) CTD Silybin CAT Text_Mining(decreases(reaction)) CTD Silybin CAT Text_Mining(increases(activity)) CTD Silybin CAT Text_Mining(decreases(activity)) CTD Silybin CXCL8 Text_Mining(increases(expression)) CTD Silybin GSR Text_Mining(decreases(reaction)) CTD Silybin GSR Text_Mining(increases(activity)) CTD Silybin GSR Text_Mining(decreases(activity)) CTD Silybin HMOX1 Text_Mining(increases(expression)) CTD Silybin HMOX1 Text_Mining(increases(reaction)) CTD Silybin IFNG Text_Mining(affects(cotreatment)) CTD Silybin IFNG Text_Mining(decreases(response to substance)) CTD Silybin MGMT Text_Mining(decreases(activity)) CTD Silybin NFE2L2 Text_Mining(affects(localization)) CTD Silybin NFE2L2 Text_Mining(increases(reaction)) CTD Silybin NFE2L2 Text_Mining(affects(cotreatment)) CTD Silybin NFE2L2 Text_Mining(increases(expression)) CTD Silybin NQO1 Text_Mining(affects(cotreatment)) CTD Silybin NQO1 Text_Mining(increases(expression)) CTD Silybin NQO1 Text_Mining(increases(reaction)) CTD Silybin TNF Text_Mining(decreases(reaction)) CTD Silybin TNF Text_Mining(increases(expression)) CTD Silybin TNF Text_Mining(affects(cotreatment)) CTD Silybin TNF Text_Mining(decreases(response to substance)) CTD Silybin UGT1A Text_Mining(decreases(activity)) CTD Silybin AHR AhR Potency (uM)=36.3021(uM) D4 PubChem Silybin ALDH1A1 Potency=14.1254(uM) D4 PubChem Silybin ALDH1A1 Potency=14125.4(nM) D4 ChEMBL Silybin CYP3A4 Potency=12.5893(uM) D4 PubChem Silybin CYP3A4 Potency=10.0(uM) D4 PubChem Silybin CYP3A4 Potency=10000.0(nM) D4 ChEMBL Silybin CYP3A4 Potency=12589.3(nM) D4 ChEMBL Silybin EHMT2 Potency=50.1187(uM) D4 PubChem Silybin EHMT2 Potency=50118.7(nM) D4 ChEMBL Silybin F2 Inhibition=None(Unspecified) D4 ChEMBL Silybin GFER None=None(uM) D4 PubChem Silybin GMNN Potency=25.929(uM) D4 PubChem Silybin HSD17B10 Potency=31622.8(nM) D4 ChEMBL Silybin HSPB1 Ratio Potency (uM)=33.4889(uM) D4 PubChem Silybin LYPLA1 None=None(uM) D4 PubChem Silybin LYPLA2 None=None(uM) D4 PubChem Silybin MRGPRX1 None=None(uM) D4 PubChem Silybin PTGER2 None=None(uM) D4 PubChem Silybin TDP1 Potency=12.9953(uM) D4 PubChem Silybin TDP1 Potency=20.5962(uM) D4 PubChem Silybin TDP1 Potency=16.7889(uM) D4 PubChem