Drug Gene Type Source Tolcapone ABCB11 Text_Mining(decreases(activity)) CTD Tolcapone COMT Text_Mining(decreases(activity)) CTD Tolcapone COMT Text_Mining(decreases(reaction)) CTD Tolcapone COMT Text_Mining(increases(abundance)) CTD Tolcapone COMT Text_Mining(decreases(abundance)) CTD Tolcapone CYP1A1 Text_Mining(decreases(reaction)) CTD Tolcapone CYP1A1 Text_Mining(increases(activity)) CTD Tolcapone CYP1A2 Text_Mining(decreases(reaction)) CTD Tolcapone CYP1A2 Text_Mining(increases(activity)) CTD Tolcapone CYP3A4 Text_Mining(increases(response to substance)) CTD Tolcapone KCNH2 Text_Mining(decreases(activity)) CTD Tolcapone SNCA Text_Mining(affects(binding)) CTD Tolcapone SNCA Text_Mining(decreases(reaction)) CTD Tolcapone UGT1A9 Text_Mining(decreases(glucuronidation)) CTD Tolcapone UGT1A9 Text_Mining(increases(glucuronidation)) CTD Tolcapone NR1H4 None=None(uM) D4 PubChem Tolcapone NR3C1 Potency-Replicate_1=34.6654(uM) D4 PubChem Tolcapone NR3C1 None=None(uM) D4 PubChem